RiteMED Cefuroxime Dosage/Direction for Use

Tablet: In general, most infections in adults and adolescents (13 years and older) will respond to 250 mg every 12 hours. However, for more severe infections, 500 mg every 12 hours may be recommended. (See Table 3.)

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Injection: Cefuroxime is given by deep intramuscular injection, by slow IV injection over 3 to 5 minutes or by intravenous infusion.
ADULT: Usual dose: 750 mg by IM or IV injection every 8 hours.
Severe infection: 1.5 g IV every 6 to 8 hours. Pneumonia: 1.5 g IM or IV injection twice daily for 48 to 72 hours followed by oral cefuroxime therapy for 7 to 10 days.
Acute exacerbations of chronic bronchitis: 750 mg IM or IV injection twice daily followed by oral cefuroxime therapy for 5 to 10 days.
Duration of both parenteral and oral therapy is determined by the severity of the infection and the clinical status of the patient.
Meningitis: 3 g IV every 8 hours.
Gonorrhea: 1.5 g IM single dose, divided between 2 different injection sites.
Surgical infection prophylaxis: Usual dose: 1.5 g IV before the procedure; this may be supplemented by 750 mg IM every 8 hours for up to 24 to 48 hours depending upon the procedure.
INFANTS AND CHILDREN: 30 to 60 mg/kg daily, increase to 100 mg/kg daily if necessary, given in 3 or 4 divided doses.
NEONATES: May be given similar total daily doses but in 2 or 3 divided doses.
Meningitis: Infants and Children: 200 to 400 mg/kg daily IV in 3 to 4 divided doses, decreased to 100 mg/kg daily after 3 days or when there is clinical improvement.
Neonates: 100 mg/kg IV daily, decreased to 50 mg/kg daily when indicated.
Impaired Renal Function: Reduce dosage of cefuroxime in patients with markedly impaired renal function.
Adults with marked renal impairment: (creatinine clearance 10-20 mL/min) 750 mg twice daily is recommended and with severe impairment (creatinine clearance <10 mL/min) 750 mg once daily is adequate.
For patients on hemodialysis: 750 mg dose should be given IV or IM at the end of each dialysis. In addition to the parenteral use, cefuroxime can be incorporated into the peritoneal dialysis fluid (usually 250 mg for every 2 liters of dialysis fluid).
Or, as prescribed by the physician.
Directions for Reconstitution: Intramuscular injection: For IM injection, add 3 mL Sterile Water for Injection to 750 mg cefuroxime. Shake gently to produce an opaque solution. Administer by deep IM injection into a large muscle mass (such as the gluteus or lateral part of the thigh). Before injecting intramuscularly, aspiration is necessary to avoid inadvertent injection into a blood vessel.
Intravenous Injection: For IV injection, add 6 mL Sterile Water for Injection to 750 mg cefuroxime. For direct intermittent IV administration, slowly inject the solution into a vein over a period of 3 to 5 minutes or give through the tubing system by which the patient is also receiving other IV solutions.
Intravenous infusion: For short intravenous infusion (e.g., up to 30 minutes) 1.5 g cefuroxime may be dissolved in 50-100 mL Sterile Water for Injection. This solution may be given directly into a vein or introduced into the tubing of the infusion set if the patient is receiving parenteral fluids.
For continuous IV infusion, a solution of cefuroxime may be added to an IV infusion pack containing one of the following fluids: 0.9% sodium chloride, 5% dextrose injection, 10% dextrose injection, 5% dextrose and 0.45% sodium chloride injection and 1/6 molar sodium lactate injection.
Solutions of cefuroxime should not be added to solutions of aminoglycosides. Each of the antibiotics can be administered separately to the same patient.
The reconstituted solution is stable for 6 hours at temperatures not exceeding 25°C (or 24 hours at 2°-8°C).